(IAGH) > Scientific Journals > GOVARESH > volume 17, Number 2, Summer, 2012
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volume 17, Number 2, Summer, 2012
  "Editorial" Esophageal Cancer in Patients with Celiac Disease
Description: MohammadHassan Emami, Ali Gholamrezaei
  "Original Article" Celiac Disease and Esophageal Cancer
Description: Masoud Khoshnia, Farhad Islami, Kariem Aghcheli, Reza Malekzadeh, Akram Pourshams.....ABSTRACT.....Background: Northeastern Iran has a high incidence for squamous cell esophageal carcinoma (ESCC). The aim of the study is to the assess relationship between celiac disease (CD) and ESCC. Materials and Methods: This was a two-part, cross-sectional, case-control study performed during 2006-2011 in Gonbad, Golestan, Iran. Serum IgA anti-tissue transglutaminase antibody levels were measured for all participants in the crosssectional study (adult general population) as well as in ESCC cases and their matched (age and gender) controls. Results: Out of approximately 1.3% of the 2202 individuals selected from the general population, 0.8% of 258 ESCC cases and 0.2% of 457 controls had positive IgA anti-tissue transglutaminase antibody levels. Conclusion: The prevalence of CD in general population of Gonbad district is a little higher than other parts of Iran. Relatively low prevalence of IgA anti-tissue transglutaminase antibody in ESCC cases in northeastern Iran does not support the presumption that CD is a major factor for the high incidence of ESCC in the region. However, as there is little higher prevalence of positivity for the antibody in ESCC cases than in controls, a cohort study of Celiac disease patients is much more suitable study to assess the relation between CD and ESCC. Keywords: Esophageal cancer; Celiac disease; Iran.....Please cite this paper as: Khoshnia M , Islami F , Aghcheli K , Malekzadeh R, Pourshams A. Celiac Disease and Esophageal Cancer.Govaresh 2012;17:73-7.....Corresponding author : Akram Pourshams , MD, MPH Digestive Disease Research Center,Shariati Hospital, Tehran University of Medical Science, North Kargar Ave. Tehran 14117, Iran Tel: + 9821 8241 5140 Fax: + 9821 8241 5400 Email : : pourshams@tums.ac.ir Received : 25 Mar. 2012 Edited : 12 May 2012 Accepted : 13 May 2012
  "Original Article" Frequency of babA2 Genotype in Helicobacter pylori from Patient with Gastroduodenal Diseases in Firoozgar Hospital in Tehran
Description: Mohammad Hasan Shirazi, Zahra pakbaz, Masoumeh Douraghi, Mohammad Reza, Pourmand, Hossein Ajdarkosh, Amir Aliramezani.....ABSTRACT.....Background: Blood group antigen binding adhesin (babA2) , is essential for attachment of Helicobacter pylori (H. pylori) to the epithelial cell layer and is the most important adhesin of H. pylori. The prevalence rate of the babA2 gene varies in different geographic areas. The aim of this study is to determine the frequency of the babA2 gene in patients with different clinical outcomes. Materials and Methods: We obtained two gastric biopsy specimens from each patient who suffered from gastrointestinal disease. Rapid urease test (RUT) was performed using one biopsy and the remaining biopsy was delivered to the laboratory for DNA extraction. Prevalence of the babA2 gene was determined using gene specific primers. Results: A total of 56 strains (68.3%) of H. pylori were babA2 positive. The prevalence of babA2 in gastric cancer patients (84.6%) was higher than seen with gastric ulcer (66.7%), duodenal ulcer (61%), and gastric patients (66.7%). There was no correlation between the babA2 genotype and clinical outcomes. Conclusion: We found that babA2 gene was more prevalent in gastric cancer but no correlation was demonstrated. However, previous studies have demonstrated a correlation of babA2 with severe H. pylori-associated diseases such as duodenal ulcers and gastric cancer. This discrepancy may be related in part to geographic diversity or sample size. Keywords: Helicobacter pylori; babA2; Gastrointestinal disease.....Please cite this paper as: Shirazi MH, pakbaz Z, Douraghi M, Pourmand MR, Azhdarkosh H, Aliramezani A. Frequency of babA2 genotype in Helicobacter pylori from Patient with Gastroduodenal Diseases in firouzgar hospital Tehran.Govaresh 2012;17:78-83.....Corresponding Author: Mohammad Hasan Shirazi, MD Division of Microbiology, Department of Pathobiology, Institute of Public Health, Tehran University of Medical Sciences, Tehran, Iran Telefax : + 98 21 88953021 E-mail: mhshirazi@tums.ac.ir Received : 29 Jan. 2012 Edited : 03 Apr. 2012 Accepted : 04 Apr. 2012
  "Original Article" Knowledge, Risk Perceptions and Behavioral Intentions among Elementary School Teachers of Yazd Regarding Hepatitis A
Description: Mohammad Hossein Baghiani Moghadam, Mehdi Mirzaei Alavijeh, Razeyeh Zolghadr.....ABSTRACT.....Background : Hepatitis A, an acute viral disease is the most common global cause of viral hepatitis that affects millions of people annually. Due to its high incidence, hepatitis A is considered a worldwide health problem. This study aims to determine the knowledge, risk perceptions, and behavioral intentions for hepatitis A among elementary school teachers in Yazd city. Materials and Methods : This was a cross-sectional study conducted in a random cluster sample of 307 people who taught at elementary schools. The data collection tool was a 30 question questionnaire that had validity and reliability in five parts: i) demographics, ii) knowledge, iii) individual risk perception, iv) general risk perception, and v) behavioral intention. The questionnaire completed by elementary school teachers in Yazd city. Results : Mean Participants age was 37.80±7.89 years with a range of 20-53 years. The score knowledge was 23.44±3.17 (range 0-34), general risk perception was 23.44±3.17 (range 7-35), individual risk perception was 6.47±2.01 (range 2-10), and behavioral intention was 16.03±3.38 (range 5-25). There were statistically significant differences between gender and mean score behavioral intention (p=0.009). Therefore women had a high level of intention. Conclusion : It seems by emphasizing increasingly of knowledge aspect who can reach behavioral intention and finally the main purpose of health education with another meaning change behavior for creating health behavior. Keywords : Knowledge; Risk perceptions; Behavioral intention; Hepatitis A.....Please cite this paper as: Baghiani Moghadam MH, Mirzaei Alavijeh M, Zolghadr R. Knowledge, Risk Perceptions and Behavioral Intentions among Elementary School Teachers of Yazd Regarding Hepatitis A.Govaresh 2012;17:84-90.....Corresponding Author: Mehdi Mirzaei Alavijeh Department of Health Education, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Telefax : + 98 311 2294362 Email : mehdimirziea@yahoo.com Received : 08 Feb.2012 Edited : 07 Apr. 2012 Accepted : 08 Apr. 2012
  "Original Article" Validation of a Revised Version of the Short-form Mc- Gill Pain Questionnaire (SF-MPQ-2) for IBS Patients
Description: Zahra Tanhaee, Ali Fathi-Ashtiani,Mohsen Amini, Homayoon Vahedi, Farhad Shaghaghi.....ABSTRACT.....Background : Background: The aim of this study was the validation of the revised McGill Pain Questionnaire (SF-MPQ-2) in patients with irritable bowel syndrome (IBS). Materials and Methods : A total of 107 (40 males, 67 females) IBS patients diagnosed according to Rome III criteria who referred to the Gastroenterology Clinic at Baqiyatallah Hospital in 1389 enrolled in this study. Enrolled patients completed a revised version of the short-form SF-MPQ-2 which had been translated into Farsi. To evaluate the validity of SF-MPQ-2 questionnaire, an exploratory factor analysis was performed. For assessment of reliability, we used Cronbach’s alpha coefficient and the split-half method test. Results : Factor analysis denoted a three-factor model that included perceptions of pain sensation, emotional pain and neuropathic pain. The validity of the SF-MPQ-2 was satisfactory according to factor analysis. A comparison between patients with pain and those without pain provided evidence that supported the criterion validity of the questionnaire. Evidence was also adequate to support the content validity of the questionnaire as a measure of pain in IBS patients. The reliability of the scales was also acceptable. Conclusion : The findings showed acceptable reliability and validity for the revised version of the short-form SF-MPQ-2 in confirming the presence of IBS. Keywords :Irritable bowel syndrome; McGill pain questionnaire; Pain; Validation.....Please cite this paper as: Tanhaee Z, Fathi-Ashtiani A , Amini M, Vahedi H, Shaghaghi F. Validation of a Revised Version of the Short-form Mc-Gill Pain Questionnaire (SF-MPQ-2) for IBS Patients.Govaresh 2012;17:91-7.....Corresponding Author: Zahra Tanhaee Department of Psychology, Payame-Noor University, Tehran, Iran Tel: + 98 21 824 824 88 Fax: + 98 21 824 824 88 Email: m.tanhae@yahoo.com Received : 30 Jan. 2012 Edited : 08 Apr. 2012 Accepted : 09 Apr. 2012
  "Original Article" New Sequential Versus Triple Treatment Schedules for Helicobacter pylori Eradication in Iran
Description: Dariush Mirsattari, Esmaeel Shamsi Afzali, Homayoun Zojaji, Nosratollah Naderi, Shohreh Almasi, Elmira Khalilimaryan, Azar Sanati, Mohammad Reza Zali.....ABSTRACT.....Background : Selection of the best approach for the treatment of Helicobacter pylori (H. pylori) infection that encompasses higher eradication and lower failure rates leads to a decline in its related complications and disorders. To understand the relative efficacy of new sequential therapy compared with standard triple therapy as two common regimens, we have performed a randomized, controlled trial to compare these two treatment protocols in an Iranian population. Materials and Methods : This study enrolled 220 patients aged 18-81 years old with dyspepsia or peptic ulcers who were candidates for endoscopy and referred to Taleghani Hospital, Tehran, Iran. Patients were randomized to receive one of two treatment regimens, a 14-day new sequential therapy that consisted of omeprazole (20 mg), amoxicillin (1.0 g), and ciprofloxacin (500 mg) administered twice daily for the first seven days, followed by omeprazole (20 mg), amoxicillin (1.0 g), and furazolidon (200 mg) administered twice daily for the remaining seven days. The second regimen comprised a proton pump inhibitor (PPI)-based triple therapy of omeprazole (20 mg), amoxicillin (1.0 g), and clarithromycin(500 mg) administered twice daily for 14 days. Results : Overall, 10 patients in PPI-based triple therapy group and 16 patients in the 14-day new sequential group stopped treatment and did not undergo 13C-urea breath testing (UBT). Among the remaining patients, the eradication rate with the PPI-based triple therapy was 89.0%, whereas it was 91.5% with the 14-day new sequential therapy which was not significantly different. No significant differences were found in eradication rates between genders in each treatment group. Adverse effects were mainly mild and comparable between the two treatment regimens. Conclusion : It seems that sequential regimen is at least as effective as standard therapy and can be used as an alternative treatment for H pylori eradication. Keywords : Helicobacter pylori; Eradication; Side effects; New sequential therapy.....Please cite this paper as: Mirsattari D, Shamsi Afzali E, Zojaji H, Naderi N, Almasi S, Khalilimaryan E, Sanati A, Zali MR. New Sequential Versus Triple Treatment Schedules for Helicobacter pylori Eradication in Iran.Govaresh 2012;17:116-21.....Corresponding author: Homayoun Zojaji, M.D Department of Gastroenterology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Telefax: + 98 21 22418885 E-mail: zojaji@yahoo.com Received :10 Feb. 2012 Edited : 10 Jun. 2012 Accepted : 12 Jun. 2012
  "Review Article" Saliva Protein Composition: An Approach to Study Biomarkers
Description: Elnaz Naderi, Sodabeh Jahanbakhsh-Ghodehkahriz, Ashraf Mohamadkhani.....ABSTRACT.....Saliva is multifunctional; it is a lubricant for speech, aide for food digestion, and protective against microorganisms. It is voluntarily accessible, composed of proteins and electrolytes, and is ideal for the early detection of a wide range of diseases. Because of a complex protein mixture, saliva proteomics has the potential to be a novel approach in the search for protein biomarkers. Most salivary proteomics research has been performed in academic institutions that study oral health. However, saliva offers a promising clinical strategy for characterizing the association between salivary protein markers and pancreatic cancer. In this review we focus on the protein composition of saliva as it represents an important field, both for the oral environment, as well as disease diagnosis and monitoring. Keywords : Protein biomarker; Saliva; Proteomics.....Please cite this paper as: Naderi E, Jahanbakhsh-Ghodehkahriz S, Mohamadkhani A. Saliva Protein Composition: An Approach to Study Biomarkers. Govaresh 2012;17:98-108.....Corresponding author: Ashraf Mohamadkhani, PhD Digestive Disease Research Center,Shariati Hospital, Tehran University of Medical Science, North Kargar Ave. Tehran 14117, Iran Tel: + 9821 8241 5400 Fax: + 9821 8241 5300 E-mail: mohamadkhani.ashraf@gmail.com Received : 05 Mar.2012 Edited : 04 May 2012 Accepted : 05 May 2012
  "Case Report" Unusual Location of Varices Presenting with Obscure Gastrointestinal Bleeding: A Case Report
Description: Farhad Zamani, Masoudreza Sohrabi, Khadijeh Hatami, Masoud Baghai-Vaji, Hossein Ajdarkosh.....ABSTRACT.....Esophagogastric varices are a frequent complication of portal hypertension. Bleeding from ectopic varices of the ileum is not only life-threatening, but its accurate diagnosis is also difficult. We have presented the case of a 31-year-old man with massive hematochezia. He was a known case of non-cirrhotic portal hypertension since 15 years prior. Conventional examination that included angiography did not define the site of bleeding. Hence, the patient underwent an intraoperative enteroscopy. The varices were located at the distal part of the ileum. Segmental resection of the ileum was performed and the patient was discharged in good condition seven days later. Intraoperative enteroscopy could be considered in the diagnostic and therapeutic management of ectopic varices. Keywords: Ileal varices; Portal hypertension; Intraoperative enteroscopy.....Please cite this paper as: Zamani F, Sohrabi M, Hatami K, Baghai-Vaji M, Ajdarkosh H. Unusual Location of Varices Presenting with Obscure Gastrointestinal Bleeding: A Case Report.Govaresh 2012;17:122-4.....Corresponding author: Farhad Zamani, MD Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran, Iran Tel: 02182141633 Fax: 02188940489 E-mail: zamani.farhad@gmail.com Received : 19 Feb. 2012 Edited : 18 Jun. 2012 Accepted : 20 Jun. 2012
  "Case Report" A Case Report of Pegylated Interferon and Bronchiolitis Oblitrans with Organizing Pneumonia
Description: Ahmad Khosravi, Mohammad Towhidi, Hassan Vosoughinia, Kamran Ghaffarzadehgan, Shahrzad M Lari, Tahmineh Tavakkoli.....ABSTRACT.....A 46-year-old woman presented with progressive dyspnea and cough. She was a known case of chronic hepatitis C (HCV) treated with pegylated (PEG)-interferon. Complete pulmonary studies and biopsy were compatible with bronchiolitis oblitrans with organizing pneumonia (BOOP) secondary to PEGinterferon. She discontinued PEG-interferon and was given a short course of steroids, after which the condition completely resolved. This report has shown that particular attention to possible side effects of PEG-interferon is necessary in the clinical practice. Keywords :Bronchiolitis oblitrans with organizing pneumonia (BOOP); pegylated (PEG)-interferon; Hepatitis C virus (HCV); Iran.....Please cite this paper as: Khosravi A, Towhidi M, Vosoughinia H, Ghaffarzadehgan K, Lari S, Tavakkoli T. A Case Report of Pegylated Interferon and Bronchiolitis Oblitrans with Organizing Pneumonia. Govaresh 2012;17:125-8.....Corresponding author: Shahrzad M Lari, MD 2199 Asrare Gharbi, Kouye doctora, 91836-33811,Mashhad,Iran Tel: +985118452146 Fax: +985118431252 E-mail: Larish@mums.ac.ir Received : 14 May. 2012 Edited : 26 Jun. 2012 Accepted : 27 Jun. 2012
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